Salts were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction. Crystal structures of API salts were determined by single-crystal X-ray diffraction. Single crystals of cocrystals were grown by the solvent evaporation method in water, ethanol, and methanol. Amoxapine has very low solubility in water, so it was cocrystallized with natural acids in a 1:1 ratio in appropriate solvents by the solvent-drop grinding method. Amoxapine is a benzox-azepine derivative and exhibits antidepressant properties. The objective of pharmaceutical cocrystalliza-tion is to create crystalline analogues that have vastly different properties, such as solubility, melting point, stability, and bioavailability from that observed in the pure active pharmaceutical ingredients (APIs). Two guided inquiry research type assignments are herein discussed that expose students to crystallography and enhance literature review/analysis skills that allows them to become better undergraduate researchers. Thus, the aim of this article is to touch upon the attempts to introduce the topic of crystallography to undergraduates of the inorganic chemistry laboratory at Georgia College and State University (GCSU). While accessibility to high-tech instrumentation is indeed an obstacle, there are educational sources that are quite accessible for undergraduate students, merely requiring a working computer to make use of them. State of the art X-ray diffraction instruments typically reach the ~$500,000 range and are rarely available to primarily undergraduate institutions. Several attempts have been made to introduce crystallography topics at the undergraduate level, but the one present obstacle is the availability of instrumentation for undergraduates to run experiments in. Chemical crystallography is considered one of the essential characterization techniques of inorganic chemistry since it is a critical tool in the structural determination of molecules small and large.
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